CCD Based Ion Image Sensors for Novel Bio Imaging-Fusion of Sensor Technology LSI Technology
Toyohashi University of Technology, Japan
The ion image sensor was invented. The device enables two dimensional visualization of both the ion and optical imaging of chemical activity of solutions and cell activity. The CMOS device consists of an array of CCDs covered with functionalized membrane. Changes in the concentration and two dimensional distributions of several ions are detected by charge accumulation.
The sensitivity of the pH imaging sensor is 100 times greater than ISFET devices and enables the determination of pH differences of 0.001 pH. The charge transfer is repeated many times, which gives huge improvements in signal to noise ratio.
We have recently reported on the use of the sensor for real time imaging of acetylcholine (ACh) enzyme reactions. Insights in the variation of the concentration of ACh may lead to new methods for the treatment of Alzheimer’s disease.
Kazuaki Sawada was born in Kumamoto, Japan in 1963. He received his B.A. and M.S. degrees in electrical and electronic engineering in 1986, 1988, respectively, and he received a Ph.D. degree in system and information engineering in 1991, all from Toyohashi University of Technology, Aichi, Japan.
From 1991 to 1998, he was a Research Associate in the Research Institute of Electronics, Shizuoka University, Shizuoka, Japan. Since 1998, he joined the Department of Electrical and Electronic Engineering, Toyohashi University of Technology, where he is now serving as a Full Professor. Prof. Sawada is a director of venture business laboratory, Toyohashi University of Technology. He was a guest professor of Technical University of Munich in 2005. His current research interests focus on the development of non label bio-image sensing devices and multimodal sensors for agriculture.